Genomics & histopathology of diffuse intrinsic pontine glioma
DIPG is a devastating paediatric brain tumour found in the brainstem of affected children. Our lab has been focusing on DIPG histology and genetics research to gain a better understanding of the biology of this tumour in order to find new treatment targets.
Recent efforts by our group have led to findings related to the clinical relevance of histone K27M-H3 mutations in DIPG (H3F3A), molecular subgroups of DIPG (MYCN, Silent and H3-K27M), as well as mutations in a novel cancer gene, ACVR1.
This research could not have happened without international collaboration and the understanding of families that DIPG tissue donation is so important to move the field forward.
We have an ongoing DIPG tissue collection protocol. Please contact us for further details.