Our research focuses on genetic and proteomic markers for prognostication and therapy guidance in paediatric brain tumours including medulloblastoma, astrocytoma and ependymoma. We developed a clinical-biologic model to predict survival in astrocytomas and are now working to acquire more detailed knowledge of the biology of astrocytomas in order to tailor therapy to the particular biology and predicted behaviour of an individual patient's tumour. To better understand the genes important for development of paediatric astrocytoma, we are using genome-wide approaches.
Through our research we have found that expression of telomerase, a protein important for continued cell division, can predict outcome in paediatric ependymoma more effectively than clinical prognostic factors and we are investigating its potential as a therapeutic target for these tumours.
In addition to our major research activities, we collaborate with a number of clinicians and scientists on projects including paediatric stroke, neuromuscular disease, mitochondrial disease and developmental disorders.
For additional information on some of the projects currently being undertaken in our lab, please see the links below.