We have developed a number of cell culture and animal models of DIPG and pHGA to characterize the oncogenic role of H3K27M and H3G34R. These models will allow us to address important questions such as:
What are the developmental consequences of H3.3K27M and H3.3G34R expression?
What is the cell of origin of DIPG and pHGA?
Is H3.3K27M and H3.3G34R tumorigenesis dependent on co-mutations?
How can we target H3.3K27M tumors?