Modelling Oncohistones

We have developed a number of cell culture and animal models of DIPG and pHGA to characterize the oncogenic role of H3K27M and H3G34R. These models will allow us to address important questions such as:

  • What are the developmental consequences of H3.3K27M and H3.3G34R expression? 

  • What is the cell of origin of DIPG and pHGA?

  • Is H3.3K27M and H3.3G34R tumorigenesis dependent on co-mutations? 

  • How can we target H3.3K27M tumors?

Mailing Address

Arthur and Sonia Labatt Brain Tumour Research Centre

The Hospital for Sick Children

Peter Gilgan Centre for Research and Learning

686 Bay Street, 17-9702
Toronto, ON  M5G 0A4